Würzburg lies in the heart of Germany and Europe.
Here three of the most important federal freeways, the A 3, A 7 and A 81, intersect.
Three international airports plus a regional district airport are located within a radius of 150 km.
As ICE rail intersection, city and region provide excellent rail links.
The river Main connects Würzburg to the European network of waterways – equally important for the transport of bulk goods and river cruise tourists.
In a linked transport system, public transport has been organized in exemplary fashion not only in the city but also in the whole district.
By car (fastest connection)
| Departure | Arrival | Distance |
| Würzburg | Frankfurt | 120 km |
| Würzburg | Stuttgart | 150 km |
| Würzburg | Munich | 280 km |
| Würzburg | Nuremberg | 115 km |
| Würzburg | Hannover | 370 km |
By Train

| Departure | Arrival | Duration |
Würzburg central | Nuremberg central | 0:54 |
Würzburg central | Frankfurt/Main airport | 1:25 |
Würzburg central | Munich central | 1:58 |
Würzburg central | Cologne central | 2:28 |
Würzburg central | Berlin central | 3:50 |
Würzburg central | Hamburg central | 3:23 |
By ship (Rhine-Main-Danube waterway)

| Departure | Arrival | Distance |
| Würzburg | Duisburg | 545 km |
| Würzburg | Rotterdam | 750 km |
Würzburg | Vienna | 655 km |
Würzburg | Donube-Black Sea estuary | 2755 km |
By plane (nearest airports)
| Departure | Arrival | Distance |
Würzburg | Giebelstadt airport | 17 km |
Würzburg | Nuremberg airport | 110 km |
Würzburg | Frankfurt/Main airport | 120 km |
Würzburg | Stuttgart | 165 km |